Journal articles: 'Blood pressure – Physiological aspects' – Grafiati (2024)

Abstract:

New techniques of noninvasive ambulatory monitoring enable multiple readings of blood pressure to be taken while people go about normal daily activities and are helping to clarify sources of blood pressure variability in health and disease. These include changes in physical and mental activity, psychosocial factors, and endogenous hormonal changes.

Abstract:

The subject of this article is the famous headstand posture and some current theories about the production of its effects of which there are an enormous number. The definitive work was published by Dr. Rao in the Journal of Applied Physiology (Ref. I& 2). The first point he considered was when one goes into the headstand position, about 400 to 500 ml of blood flows from the legs down towards the head. He measured blood pressure in the leg and found that it fell from about 200 to 10 mm Hg., average pressure. In the neck and arm, however, pressure rose by 20% (from about 90 mm Hg., to 108 mm Hg., mean blood pressure).

Abstract:

The mechanical properties of the lungs and chest wall dictate the relationship between tidal volume, flow rate and airway pressure developed during intermittent positive pressure ventilation (IPPV). The increase in intrathoracic pressures associated with IPPV has consequences for the intrapulmonary distribution of ventilation and perfusion (hence gas exchange), cardiac output and regional blood flows. Barotrauma is a potential hazard. IPPV also affects the homeostatic mechanisms that keep the air spaces dry. Strategies to maximise the benefits and minimise the side effects of IPPV include positive end-expiratory pressure, intermittent mandatory ventilation, differential lung ventilation and high frequency ventilation. Understanding the physiological effects of IPPV and associated therapies allows a rational approach to the adjustment of ventilation against pulmonary, cardiovascular and systemic responses so as to optimise gas exchange and peripheral oxygen delivery.

Abstract:

High-altitude pulmonary edema (HAPE) develops in rapidly ascending nonacclimatized healthy individuals at altitudes above 3,000 m. An excessive rise in pulmonary artery pressure (PAP) preceding edema formation is the crucial pathophysiological factor because drugs that lower PAP prevent HAPE. Measurements of nitric oxide (NO) in exhaled air, of nitrites and nitrates in bronchoalveolar lavage (BAL) fluid, and forearm NO-dependent endothelial function all point to a reduced NO availability in hypoxia as a major cause of the excessive hypoxic PAP rise in HAPE-susceptible individuals. Studies using right heart catheterization or BAL in incipient HAPE have demonstrated that edema is caused by an increased microvascular hydrostatic pressure in the presence of normal left atrial pressure, resulting in leakage of large-molecular-weight proteins and erythrocytes across the alveolarcapillary barrier in the absence of any evidence of inflammation. These studies confirm in humans that high capillary pressure induces a high-permeability-type lung edema in the absence of inflammation, a concept first introduced under the term “stress failure.” Recent studies using microspheres in swine and magnetic resonance imaging in humans strongly support the concept and primacy of nonuniform hypoxic arteriolar vasoconstriction to explain how hypoxic pulmonary vasoconstriction occurring predominantly at the arteriolar level can cause leakage. This compelling but as yet unproven mechanism predicts that edema occurs in areas of high blood flow due to lesser vasoconstriction. The combination of high flow at higher pressure results in pressures, which exceed the structural and dynamic capacity of the alveolar capillary barrier to maintain normal alveolar fluid balance.

Abstract:

High altitude is an extreme environment that challenges human beings exposed because of work, recreational activities, or habitat. Exposure to hypobaric hypoxia results in physiological adaptations in response to the geography and the associated extreme environmental conditions. These acclimatization responses can be diverse and result from evolutionary changes and comorbidities. In this context, this review aims to identify the available evidence on the effects of high altitude on blood pressure—from the physiological to clinical aspects at rest and during exercise—and the underlying mechanisms and possible clinical implications of acute and chronic intermittent hypoxia.

Abstract:

Vascular corrosion replicas provide unique three-dimensional models of both macro- and microcirculatory angio-architecture. In most replication procedures, blood is initially flushed from the vasculature with a low viscosity, non-clotting medium, such as saline, prior to infusion with the unpolymerized resin. While this removes cellular elements from the vessels and prevents coagulation, the chemical characteristics of the saline and the mode in which it is infused can potentially affect vascular smooth muscle. This can be disadvantageous if subsequent distribution of the resin does not faithfully mimic normal perfusion pathways, or if the vascular lumen is either narrowed due to vasospasm or distended due to excessive intravascular pressure. Alternatively, the composition of the saline can be modified to enhance the replication process. This may be done merely to ensure complete filling of the vasculature or to evaluate anatomical foci instrumental in physiological and pharmacological regulation of perfusion distribution.

Abstract:

This is only the second time in the long history of the International Physiological Congresses that a symposium on hypertension has formed part of the official satellite programme. After the 1983 IUPS Congress in Sydney, John Chalmers organized a magnificent satellite meeting at the Flinders Medical Centre in South Australia and we felt that we wished to continue the "tradition." Hypertension research has provided a wonderful example in recent years of how exciting it can be to apply very basic discoveries to the solution of practical problems. This meeting breaks new ground in being the first scientific event sponsored jointly by the Canadian Hypertension Society and the Australian High Blood Pressure Council. The meeting was made possible by generous financial support from Pfizer Canada and Pfizer Australia with, as co-contributors, Bayer Germany and Sandoz Australia. We would also like to acknowledge the help of Mrs. A. Garat of Pfizer Canada Medical Services in the organization of the meeting and Dr. Andrew Rankin who was responsible for all local arrangements.The Hypertension Satellite was held at Whistler, B.C., July 19–21, 1986, following the 30th International Congress of the International Union of Physiological Sciences in Vancouver. It provided a good forum for interdisciplinary information exchange. It also proved to be a pleasant social occasion in the beautiful setting of the coastal range of the Canadian Rockies. There were 48 invited speakers from Canada, Australia, Europe, the U.S.A., Japan, and New Zealand. We were fortunate in having as our patrons two great names in hypertension research, Dr. Arthur Guyton and Dr. Sydney Friedman.Emphasis was on a large range of mechanisms that regulate blood pressure. There were sessions on cell biology, the kidney, autonomic nervous regulation, peptides (including, of course, atrial natriuretic peptide and arginine vasopressin), and pathogenesis. The proceedings provide an up-to-date account of the position of the current "state of the art" in a number of important areas.

Abstract:

This paper presents a study of work shift analysis on security workload. Six security employees were investigated in this study for two work shift periods (morning and night). T - test was used to determine the differences of psychophysiological fatigue before and after working. Survey was conducted to identify some complaints. Pulse, blood pressure (systolic and diastolic), and skin temperature were also determined to define the physiological fatigue. In addition, motivation, psycho - social, and psychological complaints were identified to define the psychological fatigue by using an independent developed questionnaire. The results then shows some differences about the physical fatigue aspect in which the average are 32,2 before working and 28,2 after working. The average pulses aspects are 65.6 beats/min and 93.2 beats / min before and after working, the average blood pressure are 121,8 mm Hg and 127,7 mm Hg before and after working for systolic aspect. The average blood for diastolic aspect are 71 mm Hg and 75,9 mm H before and after working. Skin temperature is 34.8 C before working and 34.6 C after working. Result of this study also shows some differences on psychological fatigue where the mean work motivation was 21.5 before working and 24.7 after working, psycho-social was 13,5 before working and 14.3 after working, and psychological complaint was 50.8 before working and 40.83 after working.

Abstract:

AbstractIn recent years great emphasis has been placed on the role of central aortic blood pressure as measured non invasively using pulse wave analysis in pathophysiology of cardiovascular diseases and clinical aspects of hypertension. The difference of blood pressure between the central aorta and the brachial artery (amplification) is not constant but varies according to physiological, pathological and pharmacological mechanisms. Central aortic blood pressure is more strongly related to cardiovascular organ damages than does brachial pressure. Several antihypertensive drugs have different effects on aortic blood pressure as compared with brachial pressure. Central aortic blood pressure emerges superior to brachial pressure as target blood pressure in antihypertensive treatment.

Abstract:

The authors present a review of spinal cord blood supply, discussing the anatomy of the vascular system and physiological aspects of blood flow regulation in normal and injured spinal cords. Unique anatomical functional properties of vessels and blood supply determine the susceptibility of the spinal cord to damage, especially ischemia. Spinal cord injury (SCI), for example, complicating thoracoabdominal aortic aneurysm repair is associated with ischemic trauma. The rate of this devastating complication has been decreased significantly by instituting physiological methods of protection. Traumatic SCI causes complex changes in spinal cord blood flow, which are closely related to the severity of injury. Manipulating physiological parameters such as mean arterial blood pressure and intrathecal pressure may be beneficial for patients with an SCI. Studying the physiopathological processes of the spinal cord under vascular compromise remains challenging because of its central role in almost all of the body's hemodynamic and neurofunctional processes.

Abstract:

Peroxisome proliferator activated receptorγ(PPARγ) agonists are widely used in the treatment of type 2 diabetes. Side effects of drug treatment include both fluid retention and a lowering of blood pressure. Data from animal and human studies suggest that these effects arise, at least in part, from drug-induced changes in the kidney. In order to capitalize on the positive aspect (lowering of blood pressure) and exclude the negative one (fluid retention), it is necessary to understand the mechanisms of action underlying each of the effects. When interpreted with known physiological principles, current hypotheses regarding potential mechanisms produce enigmas that are difficult to resolve. This paper is a summary of the current understanding of PPARγagonist effects on both blood pressure and fluid retention from a renal perspective and concludes with the newest studies that suggest alternative pathways within the kidney that could contribute to the observed drug-induced effects.

Abstract:

During the nineties of the past century, several authors underscored the necessity of measuring blood pressure during a regular clinical examination of veterinary patients, because hypertension occurs as an accessory symptom in the course of diseased conditions. In addition to blood pressure measurements, most authors believe that it is necessary also to examine intraocular pressure, like in human medicine. Hypertension can be defined as a chronic increase of the systolic and diastolic blood pressure. Systemic blood pressure is proportionate to the heart rate and total peripheral resistance, while physiological control depends on the reninangiotensin system, aldosterone, prostaglandin, adrenergic and neurogenic factors. Some other factors can also have an influence on the measured values of blood pressure (such as age, sex, race, temperament, environment, and, in part, also how and where the pressure measurement was taken). It has been generally accepted in veterinary medicine than an animal can be considered hypertensive if the measured systolic/diastolic pressures are higher than 180/100 mm Hg. Hypertension can be primary (sometimes also defined as essential or idiopathic) when it is a consequence of several factors which include heart, neurological, kidney, endocrine, and metabolic aspects. Hypertension is defined as secondary when it occurs as a consequence of certain chronic disorders (such as hyperthyroidism, hypothyroidism, hyperadrenocorticism, pheochromocytoma, and diabetes mellitus). Blood pressure can be measured in animals using direct or indirect methods. The oscilometric and the ultrasonographic methods are equally used in the world today. Following detailed studies by large numbers of authors, the physiological frameworks of blood pressure in animals have been precisely determined. Different treatments are applied in the therapy of hypertension in animals, such as: restrictive diets, diuretics, a, and (3 blockers, blockers of calcium channels, vasodilators, ACE inhibitors. Hypertension can also be a state that requires emergency treatment, when it is resolved with aggressive therapy.

Abstract:

In recent years, there has been interest in evaluating the morbidity and mortality risk of circadian, diurnal, or nocturnal blood pressure variation. Variation is a normative property of blood pressure, necessary for survival. Like many physiological functions, blood pressure undergoes allostasis, meaning that the body does not defend a particular blood pressure value, but rather blood pressure maintains bodily stability through continual change that is initiated by constantly fluctuating internal and external environmental stimuli. Because of its allostatic and adaptive properties, the blood pressure response to unusual situations like a visit to the clinic can lead to misdiagnosis of hypertension. However, blood pressure variation is mostly ignored when evaluating hypertension, which is an arbitrary dichotomy. Whether variation is indicative of pathology should be determined by assessing its appropriateness for the circ*mstance, which requires quantification of the sources and extent of normative blood pressure responses to everyday living. These responses will vary among populations due to evolutionary genetic differences. The inconsistency of reports regarding aspects of ambulatory blood pressure variation as cardiovascular risk factors likely results from the fact that the measures used do not reflect the actual nature of blood pressure allostasis.

Abstract:

Negative intrathoracic pressure (nITP) is generated by the respiratory muscles during inspiration to overcome inspiratory resistance, thus enabling lung ventilation. Recently developed noninvasive techniques have made it possible to assess the effects of nITP in real time in several physiological aspects such as systemic blood pressure (BP), intracranial pressure (ICP), and cerebral blood flow (CBF). It has been shown that nITP from 0 to −20 cmH2O elevates BP and diminishes ICP, which facilitates brain perfusion. The effects of nITP from −20 to −40 cmH2O on BP, ICP, and CBF remain largely unrecognized, yet even nITP at −40 cmH2O may facilitate CBF by diminishing ICP. Importantly, nITP from −20 to −40 cmH2O has been documented in adults in commonly encountered obstructive sleep apnea, which justifies research in this area. Recent revelations about interactions between ICP and BP have opened up new fields of research in physiological regulation and the pathophysiology of common diseases, such as hypertension, brain injury, and respiratory disorders. A better understanding of these interactions may translate directly into new therapies in various fields of clinical medicine.

Abstract:

Aim. To study and evaluate changes in blood coagulation system in laparoscopic treatment of acute appendicitis in different pregnancy terms.Methods. In a conducted study сhanges in blood coagulation system were evaluated in 75 pregnant women in different gestation periods who underwent laparoscopic appendectomy. Gestational age was from 4-5 to 35-36 weeks. Interventions were performed with the use of endovideosurgical complex «Olympus» OTV-SC. The pressure of carbon dioxide in the abdominal cavity was within 10-12 mm Hg. The indicators of blood coagulation system were evaluated with the use of automatic coagulometer «Amelung Coagulometr KC 4A» (Trinity Biotech, Ireland). For the diagnosis of intravascular coagulation D-dimer level in blood plasma was evaluated with immunoturbodimetric assay with latex-test «Tina-quant а D-Dimer» («Roche Diagnostics», USA) in the system «Roche/Hitachi Сobas c 6000». Fibrinolytic activity was evaluated with the use of M.A. Kotovschikova and B.I. Kuznik’s method.Results. It was found that changes in hemostasis system during laparoscopic treatment of acute appendicitis in pregnant women indicate significant increase of blood coagulation potential, both before and after laparoscopic appendectomy. This state of blood clotting system can be regarded as adequate adaptive response to aggression, designed to reduce probable or actual bleeding.Conclusion. Hemostasiologic indices during laparoscopic treatment of acute appendicitis in pregnancy are characterized by a significant intensification of the blood coagulation potential, however activation of the regulatory mechanisms of blood coagulation during endovideosurgical intervention is within the physiological norms; these changes are minimal, and laparoscopic appendectomy is the method of choice for pregnant women in different periods of gestation.

Abstract:

Background: In more than half of cases of chest trauma, patients also have head injuries, abdominal injuries or polytrauma. Aim: The aim of the present study was to compare open and closed treatment for chest injuries according to mortality, hospitalization, trauma indices and physiological data. Method: Three hundred sixty-seven patients (293 males and 74 females) with an Anatomic Injury Scale (AIS) score of 2 or more for thoracic trauma were evaluated. The following aspects were evaluated associations between treatment (open and closed) for chest injury, discharge from hospital, hospitalization and death, Trauma indices Revised Trauma Score (RTS), Injury Severity Score (ISS) and TRISS, Blood pressure, diastolic pressure, respiratory rate and pulse. Results: No significant associations were found between the type of treatment (open or closed procedure) and discharge from hospital, hospitalization or death (p = 0.3).No significant associations were found between the type of treatment (open or closed procedure) and the trauma indices, blood pressure, pulse or respiratory rate.

Abstract:

The aim of this paper is to highlight the aspects of the baroreflex control of the cardiovascular system that could be relevant to the analysis and modelling of cardiovascular oscillations and regulation. In particular, complex and/or controversial issues of the baroreflex control are addressed on the basis of results obtained in previous studies by others as well as by our group. Attention has been focused on time-variant and nonlinear characteristics of the baroreflex function and on the influence of this physiological mechanism on different frequency regions of blood pressure and heart rate spectra.

Abstract:

Natriuretic peptides (NPs) exert diverse effects on several biological and physiological systems, such as kidney function, neural and endocrine signaling, energy metabolism, and cardiovascular function, playing pivotal roles in the regulation of blood pressure (BP) and cardiac and vascular homeostasis. NPs are collectively known as anti-hypertensive hormones and their main functions are directed toward eliciting natriuretic/diuretic, vasorelaxant, anti-proliferative, anti-inflammatory, and anti-hypertrophic effects, thereby, regulating the fluid volume, BP, and renal and cardiovascular conditions. Interactions of NPs with their cognate receptors display a central role in all aspects of cellular, biochemical, and molecular mechanisms that govern physiology and pathophysiology of BP and cardiovascular events. Among the NPs atrial and brain natriuretic peptides (ANP and BNP) activate guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA) and initiate intracellular signaling. The genetic disruption of Npr1 (encoding GC-A/NPRA) in mice exhibits high BP and hypertensive heart disease that is seen in untreated hypertensive subjects, including high BP and heart failure. There has been a surge of interest in the NPs and their receptors and a wealth of information have emerged in the last four decades, including molecular structure, signaling mechanisms, altered phenotypic characterization of transgenic and gene-targeted animal models, and genetic analyses in humans. The major goal of the present review is to emphasize and summarize the critical findings and recent discoveries regarding the molecular and genetic regulation of NPs, physiological metabolic functions, and the signaling of receptor GC-A/NPRA with emphasis on the BP regulation and renal and cardiovascular disorders.

Abstract:

<em>Elderly is a term for an individual who has entered the period of late adolescence or old age. The number of elderly in the province of Bali in 2018 reached 572.518 inhabitants. Elderly degeneration in terms of both aspects of the psychological and physiological aspects. One form of setbacks is a sleep disorder (insomnia). Insomnia is a disorder of the quantity and quality of sleep that inhibit its function. The elderly who suffer from insomnia to be an increase in sympathetic activity will increase blood pressure and decreased parasympathetic activity lowers blood pressure, in which blood pressure is influenced by the autonomous system that is sympathetic and parasympathetic. This study aims to determine the correlation betweeninsomnia with blood pressure in the elderly in Banjar Wangaya Kaja the work area of Public Health Center III North Denpasar. This research is an analytic correlational research aimed to see whether or not the correlation insomnia with blood pressure exist in the elderly by using cross sectional approach. The sample consisted of 88 respondents to the sampling technique used purposive sampling. Collecting data using questionnaires insomnia and blood pressure measurements using a mercury sphygmomanometer. Most elderly people experience severe insomnia that 68 (77.3%), and as many as 58 people (65.9%) of elderly hypertensive level 1. Based on the results-Spearman rank correlation test in getting the results p (value) = 0,000 &lt;0 , 05 then Ho is rejected and Ha accepted which means there is a significant correlation between insomnia with blood pressure in the elderly in Banjar Kaja Wangaya. The results showed a correlation coefficient of r = 0,702,, it means the correlation is in a strong level, the positive direction of correlation means the higher the insomnia in the elderly, the higher blood pressure will be</em>

Abstract:

Introduction: The circadian pattern of blood pressure is characterized by a physiological drop occurring after sleep onset. The alteration of this phenomenon (non-dipping, extreme dipping, or reverse dipping) is associated with an increased cardiovascular risk. Besides altered autonomic and endocrine circadian rhythms, psychological aspects seem to play a role in this modification. However, the few studies that have analyzed the influence of psychological dimensions on the dipping phenomenon have reported inconsistent results. This study aimed to examine the relationship between anger expression and blood pressure (BP) dipping. Methods: We obtained 24 h ambulatory BP measurements from 151 participants and used them to define three groups according to their dipping status: Dippers (N = 65), Non-Dippers (N = 42), and Extreme Dippers (N = 44). Sociodemographic and anamnestic information was collected, and the State–Trait Anger Expression Inventory was used to assess anger. Results: Analysis of variance evidenced significant higher scores for Trait Anger Temperament and Anger Expression in Extreme Dippers than in both Dippers and Non-Dippers. However, after controlling for confounding variables, there was no significant relationship with trait anger, and only the result concerning the suppression of anger was confirmed. Conclusions: These findings suggest that the analysis of some psychological factors, such as anger, could be necessary to better understand differences in nocturnal BP alterations. Trait anger and suppression of anger may contribute to the description and classification of patients who exhibit a maladaptive dipping phenomenon. However, modifiable (i.e., cigarette consumption) and unmodifiable (i.e., age) risk factors appear to mediate this relationship. Although further studies are necessary to explore this association, these results highlight that some aspects of anger can represent risk factors or markers of maladaptive modulation of the dipping phenomenon.

Abstract:

Abstract Frontotemporal dementia (FTD), a neurodegenerative disease broadly characterized by socioemotional impairments, includes three clinical subtypes: behavioral variant FTD (bvFTD), semantic variant primary progressive aphasia (svPPA) and non-fluent variant primary progressive aphasia (nfvPPA). Emerging evidence has shown emotional reactivity impairments in bvFTD and svPPA, whereas emotional reactivity in nfvPPA is far less studied. In 105 patients with FTD (49 bvFTD, 31 svPPA and 25 nfvPPA) and 27 healthy controls, we examined three aspects of emotional reactivity (physiology, facial behavior and subjective experience) in response to a sad film. In a subset of the sample, we also examined the neural correlates of diminished aspects of reactivity using voxel-based morphometry. Results indicated that all three subtypes of FTD showed diminished physiological responding in respiration rate and diastolic blood pressure; patients with bvFTD and svPPA also showed diminished subjective experience, and no subtypes showed diminished facial behavior. Moreover, there were differences among the clinical subtypes in brain regions where smaller volumes were associated with diminished sadness reactivity. These results show that emotion impairments extend to sadness reactivity in FTD and underscore the importance of considering different aspects of sadness reactivity in multiple clinical subtypes for characterizing emotional deficits and associated neurodegeneration in FTD.

Abstract:

This study aimed to establish a health and medical foundation for forest healing programs and provide a basis for developing an evaluation system for such programs. While the number of visitors to forests and interest in forest healing effects are increasing, few studies have examined the various indicators of the persistent changes in forest healing effects. Therefore, this study conducted pre-, post-, and follow-up experiments on 87 health and clinical indicators in a sample of 88 adolescent participants. The relationships between pre-, post-, and follow-up experiment results for each indicator were analyzed. Of the 87 indicators, 46 showed significant changes, including systolic blood pressure, diastolic blood pressure, cholesterol, serotonin, vitamin D, CD16+CD56 count, interferon-γ, resilience, and self-esteem. The findings are significant for studying diverse participants and indicators and lay the foundation for developing forest healing programs by clarifying aspects such as the indicators suitable for short-term observation versus the indicators requiring long-term observation. Based on these analyses, the results of this study are expected to be useful when conducting research to establish an evidence-based forest healing program in the future.

Abstract:

Abstract The cloning of angiotensin II (Ang II) receptor genes and the availability of specific receptor ligands allows characterization of Ang II receptor-mediated actions. Most of the well-known Ang II effects such as vasoconstriction, drinking response and cell proliferation are mediated through the AT1 receptor. Little is known about the physiological effect of the AT2 receptor, though there are some reports describing the involvement of the AT2 receptor in blood pressure regulation. Recent data demonstrate that the AT2-mediated actions are inhibitory to AT1- and mitogen-induced growth effects, indicating a balancing mechanism for Ang II-controlled mechanisms. It has also been demonstrated that AT2 receptor inactivation induces endothelial cell proliferation in the presence of Ang II. Additionally, AT2 receptor activation enhances nerve growth factor-induced differentiation of PC12W cells and a role in apoptotic changes has also been reported. Based on recent findings, this article focuses on the role of Ang II in growth and differentiation processes with respect to the AT2 receptor in these events. European Journal of Endocrinology 136 349–358

Abstract:

Stress can be viewed in terms of the contribution of urbanization, lifestyle changes and the ameliorating potential of nature related environments. This study explored the influence of temperature and humidity of the mountain landscape environment on the physiological indices of individuals. 38 respondents formed a single within-group study sample. Measures of Physiological indices including blood pressure, pulse rate and respiratory rate as well as ambient environment conditions were carried out both at the urban and mountain landscape environments. Findings imply that temperature and humidity are aspects of the mountain landscape environment conditions that combine to influence human physiological wellbeing. Therefore, Individuals confronted with many sources of stress from daily engagements in urban environments can obtain short term relief in the mountain landscape environment.

Abstract:

Hypovolemic and orthostatic challenge can be simulated in humans by the application of lower body negative pressure (LBNP), because this perturbation leads to peripheral blood pooling and, consequently, central hypovolemia. The classic paper by Foux and colleagues clearly shows the effects of orthostasis simulated by LBNP on fluid shifts and homeostatic mechanisms. The carefully carried out experiments reported in this paper show the interplay between different physiological control systems to ensure blood pressure regulation, failure of which could lead to critical decreases in cerebral blood flow and syncope. Here, a teaching seminar for graduate students is described that is designed in the context of this paper and aimed at allowing students to learn how Foux and colleagues have advanced this field by addressing important aspects of blood regulation. This seminar is also designed to put their research into perspective by including important components of LBNP testing and protocols developed in subsequent research in the field. Learning about comprehensive protocols and carefully controlled studies can reduce confounding variables and allow for an optimal analysis and elucidation of the physiological responses that are being investigated. Finally, in collaboration with researchers in mathematical modeling, in the future, we will incorporate the concepts of applicable mathematical models into our curriculum.

Abstract:

Abstract Peripheral blood pressure measurement (Finapres technique) is a promising development in activation research. This paper tests and compares the temporal stability and covariation of peripheral and brachial blood pressure responses. Forty healthy subjects were tested four times at intervals of 1 day, 1 week, and 1 month. The tasks employed were two mental tasks (mental arithmetic and a Color Word Test) and a static (fingergrip) task. Recorded physiological parameters were peripheral and brachial systolic (SBP) and diastolic blood pressure (DBP). Mean peripheral SBP was about 20 mmHg higher than brachial SBP, but the difference between the DBP measures was negligible. Correlations between peripheral and corresponding brachial BP resting levels were low, with coefficients below 0.30. The correlations between peripheral and brachial SBP and DBP were higher for reactivity (change) scores (0.46-0.82) than for resting scores. Several types of inter- and intraindividual covariation were calculated to provide a deeper understanding of the relationship between the physiological parameters with respect to their dynamics. Temporal stability of peripheral BP level scores was lower (0.37-0.57) than for brachial BP (0.59-0.77), but the stability of the change scores was similar for both BP techniques. The results show that it is important to distinguish between several aspects of the mutual relationship between peripheral and brachial BP measures. Peripheral BP measurements are not suited to assess the BP level of a subject, but they are very useful to assess cardiovascular reactivity.

Abstract:

The main purpose of the present study was to examine the relationships between measures of fitness [estimated peak oxygen consumption (V̇o2 peak) and handgrip strength] and forearm vascular function in 55 young (22.6 ± 3.5 yr) adults. In addition, the present study considered methodological and technical aspects regarding the examination of the venous system using mercury in-Silastic strain-gauge plethysmography (MSGP). Forearm venous capacitance and outflow were examined using five different [7, 14, 21, 28, and 35 mmHg < diastolic blood pressure (DBP)] venous occlusion pressures and after a 5- and 10-min period of venous occlusion. A pressure of 7 mmHg < DBP and a period of 10 min venous occlusion produced the greatest ( P < 0.05) venous capacitance and outflow, without altering arterial indexes. Reproducibility of forearm arterial and venous indexes were evaluated at rest and after 5 min of upper arm arterial occlusion at 240 mmHg on three different occasions within 10 days with the interclass correlation coefficient ranging from 0.70 and 0.94. Estimated V̇o2 peak correlated with postocclusion arterial inflow ( r = 0.54, P = 0.012) and resting venous outflow ( r = 0.56, P = 0.016). Finally, handgrip strength was associated with venous capacitance ( r = 0.57, P = 0.007) and outflow ( r = 0.67, P = 0.001). These results indicate that the examination of forearm vascular function using MSGP is reproducible. Moreover, the data show the importance of careful consideration of the selection of venous occlusion pressure and period when implementing these measures in longitudinal trials. Finally, the associations between fitness and venous measures suggest a link between venous function and exercise performance.

Abstract:

Elevated intra-abdominal pressure (IAP) occurs in many clinical settings, including sepsis, severe acute pancreatitis, acute decompensated heart failure, hepatorenal syndrome, resuscitation with large volume, mechanical ventilation with high intrathoracic pressure, major burns, and acidosis. Although increased IAP affects several vital organs, the kidney is very susceptible to the adverse effects of elevated IAP. Kidney dysfunction is among the earliest physiological consequences of increased IAP. In the last two decades, laparoscopic surgery is rapidly replacing the open approach in many areas of surgery. Although it is superior at many aspects, laparoscopic surgery involves elevation of IAP, due to abdominal insufflation with carbonic dioxide (pneumoperitoneum). The latter has been shown to cause several deleterious effects where the most recognized one is impairment of kidney function as expressed by oliguria and reduced glomerular filtration rate (GFR) and renal blood flow (RBF). Despite much research in this field, the systemic physiologic consequences of elevated IAP of various etiologies and the mechanisms underlying its adverse effects on kidney excretory function and renal hemodynamics are not fully understood. The current review summarizes the reported adverse renal effects of increased IAP in edematous clinical settings and during laparoscopic surgery. In addition, it provides new insights into potential mechanisms underlying this phenomenon and therapeutic approaches to encounter renal complications of elevated IAP.

Abstract:

BACKGROUND: Direct monitoring of arterial blood pressure provides continuous, real-time information about patients' physiological status. Critical care nurses set up and maintain monitoring systems and use the obtained data to guide clinical decisions. Inaccurate measurements may lead to misdiagnosis and mismanagement. PURPOSE: To describe critical care nurses' knowledge in 3 content areas related to direct monitoring of arterial blood pressure: physiology, technical aspects, and waveform and data interpretation. METHODS: Via poster advertisem*nts, 391 critical care nurses in 6 intensive care units at 2 hospitals were invited to complete an 18-item, criterion-referenced questionnaire on monitoring arterial blood pressure and a demographic data sheet. Summary statistics were used to analyze data from 68 subjects. Analysis of variance was used to determine if total and subset scores differed among demographic subgroups. RESULTS: Scores ranged from 11.1% to 61.1% correct answers, with a mean of 36.7% (SD, 11.8%). Item analysis indicated a knowledge deficit in all content areas at all cognitive levels. Questions with highest scores addressed waveform damping and using mean arterial pressure to guide treatment; lowest scores were related to dynamic response characteristics and reflected pressure waves. Mean scores did not differ among demographic subgroups. CONCLUSIONS: The results suggest a general knowledge deficit in arterial blood pressure monitoring. This study should be replicated on a larger scale to validate its findings and to improve the validity and reliability of the research tool. National research-based standards of practice for hemodynamic monitoring should be developed and disseminated among critical care nurses.

Abstract:

This article investigates the two-dimensional creeping flow of a non-Newtonian micropolar fluid in a small width permeable channel. Fluid is absorbed through permeable walls at a variable rate. This situation arises in filtration and mass transfer phenomena in industrial and engineering processes. The exact solution of the equations of motion is obtained. Graphs of the velocity profiles and pressure drop reveal the significant impact of the non-Newtonian nature of the micropolar fluid on the flow. The obtained solutions are used to discuss the hydrodynamical aspects of the physiological phenomenon of blood filtration in an artificial kidney, the flat plate dialyzer (FPD). Expressions for finding the ultrafiltration rate and mean pressure drop in an FPD are derived. Ultrafiltration rate and the mean pressure difference in an FPD are computed using derived expressions. A comparison of these with the existing empirical and experimental results shows a good agreement. For certain values of parameters, the derived form of the flow rate reveals that the axial flow rate in an FPD decays exponentially along the membrane length. This is a well-established and admitted result used by several researchers for studying the hydrodynamics of blood flow in renal tubules of kidneys. It is concluded that the presented model can be used to study the hydrodynamical aspects of blood flow in an FPD.

Abstract:

Extracorporeal lung assist (ECLA) is an established treatment of severe pulmonary failure. Since extracorporeal perfusion is applied in a long-term fashion in this setting, the negative impact on blood compounds is of tremendous importance. Pumpless arteriovenous ECLA (av-ECLA) is an alternatively introduced technique that focuses on reduced blood traumatization. However, due to determining technical and physiological aspects, its clinical application is limited to a highly selected group of patients. Membrane oxygenators with minimal pressure gradients, as well as stable patients’ haemodynamics providing a sufficient cardiac output, are the most important prerequisites. With respect to recent reports, characteristic features of av-ECLA, with special emphasis on its physiological background, are reviewed. Accordingly, reasonable indications for its beneficial use are discussed. It is concluded that av-ECLA is a feasible technique when its limitations are accepted. For adequate clinical use, more data concerning indications, as well as time- and technique-related directions are required.

Abstract:

1. Mechanical forces associated with blood flow play important roles in the acute control of vascular tone, the regulation of arterial structure and remodelling and the localization of atherosclerotic plaque. Uraemia is a proatherogenic process and is expected to be associated with impaired vascular reactivity. 2. To study this, 12 male Wistar rats were rendered uraemic by five-sixths nephrectomy and 12 control rats were sham operated simultaneously. After 8 weeks a tail-cuff systolic blood pressure was recorded, blood samples were taken and the animals killed. Isolated femoral arteries were dissected and mounted on a pressure myograph and myogenic tone was assessed over a range of intravascular pressures from 40 to 160 mmHg. Histologically the arteries were comparatively examined for gross morphology, calcification and deposition of collagen. 3. Biochemically the serum urea and creatinine were greater in the uraemic compared with the control rats (urea: 23.5±6 mmol/l and 6.8±01 mmol/l respectively, P not significant; creatinine: 130.7±13 mmol/l and 70.3±5 mmol/l respectively, P < 0.01) but systolic blood pressure was the same in both groups (control, 97±1 mmHg; uraemic, 98±2 mmHg), compatible with mild uraemia. 4. Myogenic tone was significantly greater in uraemic vessels (7.3±1.8% versus 2.3±0.4% in control, P = 0.01). The actual vessel lumen diameter was also smaller in pressurized uraemic vessels compared with control vessels (471±30 μm versus 604±33 μm, P< 0.01) after equilibration in physiological salt solution. However, when incubated in calcium-free physiological salt solution, the passive internal diameter was similar in uraemic vessels (538±25 μm compared with 595±31 μm in control). Histologically, there were no differences between the two groups. 5. We conclude that some aspects of vascular reactivity are altered in mild experimental uraemia as shown by a reduced internal lumen diameter and increased myogenic tone. Furthermore, these changes are apparent in the absence of hypertension and precede structural changes.

Abstract:

Increasing physical activity has been shown to reduce physiological markers of cardiovascular disease, such as high blood pressure, vascular endothelial cell reactivity and arterial stiffness. In this issue of Clinical Science, Hägg and colleagues have chosen the spontaneously hypertensive rat model to investigate the effect of exercise on vascular function. They found that spontaneous running increased aortic compliance and antioxidant capacity with decreased oxidative stress in mesenteric arteries, presenting support for the cardiovascular protective effects of physical activity. Two important aspects of their study include the magnitude of the running stimulus and the choice of artery to evaluate.

Abstract:

Atherosclerosis (stenosis) is a common cardiovascular disease in which the blood vessel restructures by narrowing, thickening and gets hardened due to the deposition of plaque. A detailed study of narrowing of arteries applying computational aspects which leads to better findings in order to know the underlying mechanics of development and progression of such diseases. Such kind of analysis can be a useful tool for the medical professionals to study the realistic physiological conditions. They can simulate and observe the blood flow in arteries. In the present study, a case of normal and stenosed carotid bifurcation is simulated. The models are generated in CATIA based on the clinical data obtained from a patient using Ultrasound Doppler. A transient FSI analysis considering Newtonian behavior is performed to compare the significance of High Blood Pressure (HBP) and Normal Blood Pressure (NBP) on carotid bifurcation. The FSI simulation is carried out for both HBP and NBP conditions for several pulse cycles on normal and stenosed models using ANSYS13.0 to demonstrate the changes in flow behavior at various sections of the model. The computed results agree well with clinical observations and available literature as seen in case of NBP.

Abstract:

Nitric oxide (NO) is produced by and relaxes pulmonary arteries and veins; however, a role for NO as a participant in the control of pulmonary vascular resistance (PVR) remains to be defined. Here we investigated the hypothesis that for NO to serve as a determinant of PVR in the rabbit requires the presence of blood. In isolated blood-perfused rabbit lungs, NG-nitro-L-arginine methyl ester (L-NAME, 100 microM) increased PVR and the slope of the pressure-flow relationship. These effects of L-NAME were prevented by pretreatment with L-arginine. In contrast, in lungs perfused with a physiological salt solution, L-NAME had no effect on PVR or the pressure-flow relationship. The addition of washed red blood cells (RBCs) to physiological salt solution, but not the addition of plasma and platelets, restored the response to L-NAME. This effect of RBCs was not reproduced by increasing perfusate viscosity with dextran. These results suggest that, in the rabbit lung, NO is a determinant of PVR in the presence of blood. Moreover, that aspect of blood that permits the generation of NO appears to be related to the RBC and not to perfusate viscosity.

Abstract:

One of the most important physiological parameters of the cardiovascular circulatory system is Blood Pressure. Several diseases are related to long-term abnormal blood pressure, i.e., hypertension; therefore, the early detection and assessment of this condition are crucial. The identification of hypertension, and, even more the evaluation of its risk stratification, by using wearable monitoring devices are now more realistic thanks to the advancements in Internet of Things, the improvements of digital sensors that are becoming more and more miniaturized, and the development of new signal processing and machine learning algorithms. In this scenario, a suitable biomedical signal is represented by the PhotoPlethysmoGraphy (PPG) signal. It can be acquired by using a simple, cheap, and wearable device, and can be used to evaluate several aspects of the cardiovascular system, e.g., the detection of abnormal heart rate, respiration rate, blood pressure, oxygen saturation, and so on. In this paper, we take into account the Cuff-Less Blood Pressure Estimation Data Set that contains, among others, PPG signals coming from a set of subjects, as well as the Blood Pressure values of the latter that is the hypertension level. Our aim is to investigate whether or not machine learning methods applied to these PPG signals can provide better results for the non-invasive classification and evaluation of subjects’ hypertension levels. To this aim, we have availed ourselves of a wide set of machine learning algorithms, based on different learning mechanisms, and have compared their results in terms of the effectiveness of the classification obtained.

Abstract:

The article contains a literature review devoted to research on the influence of odours on physiological, emotional, and cognitive aspects of human health. The following databases were used at literature search execution: Pubmed, Scopus, Web of Science, MedLine, Global Health, Russian Research Citation Index. A total amount of 60 sources was analyzed for 1983-2019. The experimental research results aimed at studying the influence of odours on such physiological indices a: heart rate, heart rate variability, arterial blood pressure, respiratory rate, skin conductibility reaction, sleep, are described, and emotional and cognitive characteristics of the test subjects. The response to odours exposure was shown to depend on their intensity, hedonistic tone, the chemical structure of the odorant, as well as individual peculiarities of the test subjects, including their past experiences with smelling. In most cases, exposure to unpleasant odours activates the sympathetic nervous system, therefore heart rate, respiratory rate, skin blood circulation and its conductivity increase. Attention concentration increases at the deterioration of cognitive functions. Anger and repulsion reactions are noted at the emotional level; a feeling of discomfort with a motivation to escape appears. The exposure of pleasant odours leads to parasympathetic nervous system activation, heart rate, respiratory rate, skin conductibility, and blood circulation decrease. Cognitive functions improve, the quality of problem-solving increases, attention concentration decreases. A person’s mood gets better; the sensation of happiness appears. At that literature analysis has revealed most of the studies on the human to have significant restrictions: standard exposure methods absence, the difficulty of execution blind experiments that were deemed to be ignorant by test subjects as well as the influence of individual preferences and previous personal experience on the effects generated by the odour. The authors proposed recommendations on the current restrictions prevention and optimization of conducting the experimental research on the influence of odours on humans.

Abstract:

Abstract Introduction: Non-thermal atmospheric pressure dielectric barrier discharge plasma (cold plasma due to its non-thermal nature) has emerged as a promising new tool in medicine due to its ability to coagulate blood rapidly, sterilize tissue without thermal damage and induce apoptosis in malignant tissue. The potential clinical applicability of non-thermal plasma lies in its use in controlling intra-operative microvascular bleeding in organs and in endoscopy. Non-thermal plasma can also be used to treat superficial wounds in trauma through hemostasis while simultaneously inducing surface sterilization. We have previously demonstrated that non-thermal plasma hastens blood coagulation on cut tissue surfaces and accelerates clot formation in whole blood five times faster than natural coagulation. A series of experiments were undertaken to investigate the mechanism of coagulation by non-thermal plasma. Methods/Results: We initially postulated that changes in pH and/or extracellular Ca2+ as a possible mechanism for non-thermal plasma mediated coagulation. Our studies however showed no significant changes in pH or Ca2+ in treated blood. Thermal energy triggered coagulation as seen in conventional electrocautery as well as electric field effects were eliminated as other possible mechanisms. The role of reactive oxygen species (ROS) in coagulation was studied, as non-thermal plasma is known to produce ROS in water. ROS production in blood was blocked with sodium pyruvate, an ROS scavenger, and the results showed no effect on non-thermal plasma induced coagulation. Specific effects of non-thermal plasma on citrated blood samples revealed extremely rapid coagulation with surface gel formation, while clotting studies (PT, aPTT) performed on the plasma beneath the gel revealed consumption of coagulation factors. Examination of the clot formed by non-thermal plasma using Scanning Electron Microscopy (SEM) showed platelet activation with pseudopodia formation, aggregation, and fibrin formation. The effects of non-thermal plasma on fibrinogen solution treated at physiologic pH showed a change in opacity suggesting clot formation. Dynamic Light Scattering (DLS) was used to measure particle size distributions of treated and untreated fibrinogen solutions. Treated fibrinogen exhibited a multi-modal distribution of sizes with the largest size corresponding to the size of fibrin-like structures. This suggests that non-thermal plasma may coagulate blood by the conversion of fibrinogen to fibrin. Evaluation of albumin, our control protein given its non-involvement in coagulation, showed no changes upon exposure to non-thermal plasma. Conclusion: Non-thermal plasma likely promotes coagulation by enhancing the physiologic coagulation process through direct activation of fibrinogen as well as platelet activation and aggregation. Future research will further evaluate the mechanisms of non-thermal plasma induced platelet activation and effects on other proteins in the coagulation cascade. This will lead to newer insights into the physiological aspects of coagulation and clinical utility of non-thermal plasma in medicine.

Abstract:

We consider the aspects of adaptation to the process of training and physical education of first year cadets. Problems and aspects of physiological adaptation are designated and its connection with activity of cardiovascular system of an organism of first year cadets is shown. The main factor of the considered process of physiological adaptation is shown. The relevance of the study of adaptive mechanisms of the body of first year cadets during the beginning of their training in the military university is proved. The necessity of increasing the volume of physical activity for more successful adaptation of first year cadets to training in a military university is proved. Reflects the results of exposure to prolonged and regular physical activity, compatible with the normal functioning of the organism in which the person developing his adaptive functional reorganization. Studies of functional possibilities of cardiovascular system of first year cadets to specify Robinson's index (for the purpose of quantitative characteristics of the systolic heart function). The estimation of these parameters is necessary to complete the definition of adaptation possibilities of organism of first year cadets. The results of the study of heart rate, systolic blood pressure at rest are also reflected. All studies are aimed at determining the effectiveness of the implementation of the developed system of physical education of first year cadets, aimed at improving the adaptive capacity of their body, to improve the educational process in the military university.

Abstract:

In order to study the LED light source illumination and the correlated color temperature effect on the human eye visual performance and physiological changes, through the comparative experiments of visual task performances under the different color temperature (3000K low color temperature, 4000K intermediate color temperature) and the different illumination (1145lux high intensity, 500lux middle intensity, 288lux low illumination), study the relationship between the biological effect and visual performance from two aspects of the visual perception performance and the physical efficiency such as blood pressure and pulse. Research indicates that color temperature 3000K or 4000K, intensity of illumination in about 500lux LED light source is suitable to visual task.

Abstract:

Imidazoline receptor agonists are one of the groups of contemporary antihypertensive drugs with the pleiotropic cardiovascular effects. In this review, the historical, physiological, pathophysiological aspects concerning imidazoline receptor agonists and possible mechanisms for their participation in endothelioprotection were considered. Illuminated the molecular biology of each subtype of imidazoline receptors and their significance in the pharmacological correction of cardiovascular disease. IR type 1 are localized in the brain nucleus, carrying out the descending tonic control of sympathetic activation, as well as in the endothelial cells of the vessels and kidneys. Their activation leads to a decrease in blood pressure, slowing the remodeling of the vascular wall and increasing sodium nares. IR type 2 is expressed predominantly in the adrenal gland, fat and muscle tissues. The physiological effects of their stimulation are associated with an increase in glucose utilization by peripheral tissues. IR type 3 are mainly present in pancreatic cells and are associated with the regulation of insulin secretion. Their stimulation leads to an increase in insulin liberation. Thus, IR agonists are able to improve endothelial function through various mechanisms, including blood pressure reduction, improvement in metabolic profile, and direct positive effects on the vascular wall. Current information on the pharmacological effects of this group compounds allows us to conclude that they are a promising group for correcting endothelial dysfunction and complications associated with it.

Abstract:

The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. NPs have also been implicated in the pathogenesis of several cardiovascular diseases (CVDs), including hypertension, atherosclerosis, heart failure, and stroke. A fine comprehension of the molecular mechanisms dependent from NPs and underlying the promotion of cardiovascular damage has contributed to improve our understanding of the molecular basis of all major CVDs. Finally, the opportunity to target NPs in order to develop new therapeutic tools for a better treatment of CVDs has been developed over the years. The current Special Issue of the Journal covers all major aspects of the molecular implications of NPs in physiology and pathology of the cardiovascular system, including NP-based therapeutic approaches.

Abstract:

Objectives: To examine the magnitude of impact of two nature-themed window murals on physiological processes, as measured by heart rate and blood pressure, of pediatric patients. Background: Many children and adolescents find at least one aspect of the hospitalization process frightening or anxiety provoking. One physical feature linked to stress reduction is access to positive distractions. Views of nature are one of the most common forms of positive distractions in healthcare environments. Patient room windows are the most common way patients are exposed to natural elements. Exposure to views of nature is linked to a number of positive impacts on physiological outcomes. Unfortunately, not every patient room will be able to provide a nature-filled window view. In situations where nature scenes do not occur, enhanced nature views may be utilized to replicate many of the same benefits as actual nature views. Methods: Pediatric patients were randomly assigned to one of the three room conditions: aquatic window mural, tree window mural, or control condition. The medical data of participants ( n = 90) who stayed in the rooms were gathered and evaluated for differences. Results: Data analysis supports the notion that patient stress is heightened at the time of admission. Patients in the rooms with murals were found to have improvements in heart rate and systolic blood pressure in comparison to patients in control rooms, suggesting that the murals had an impact on physiological processes. Data also suggest that subject matter played a role, as patients in tree murals rooms had the most health-related outcomes.

Abstract:

AbstractMultimodality monitoring provides insights into the critically ill brain-injured patient through the assessment of biochemical, physiological, and electrical data that provides insight into a patient's condition and what strategies may be available to limit further damage and improve the odds for recovery. Modalities utilized include evaluation of intracranial pressure along with cerebral perfusion pressure to determine adequate blood flow; continuous electroencephalography to protect the patient from seizures and to identify early functional manifestations of ischemia and toxicity; transcranial Doppler evaluation for bedside review of circulatory adequacy; tissue oxygen monitoring to establish that brain tissue is receiving adequate oxygen from blood flow; and microdialysis to evaluate the metabolic function of the tissue in areas of concern. These monitors provide insights regarding specific aspects of brain tissue and overall brain function in the critically ill patient. Although recommendations continue to evolve for therapeutic targets for each of these modalities, an effective clinician may use each of these modalities to evaluate patients on an individual basis to improve the outcome of each patient, tailoring management to provide the care needed for any unique clinical presentation.

Abstract:

Over the past years self-tracking of physiological parameters has become increasingly common: more and more people are keeping track of aspects of their physiological state (e.g., heart rate, blood sugar, and blood pressure). To shed light on the possible effects of self-tracking of physiology, a study was conducted to test whether physiology feedback has acute effects on self-reported stress and the extent to which self-reported stress corresponds to physiological stress. In this study, participants executed several short tasks, while they were either shown visual feedback about their heart rate or not. Results show that self-reported stress is more in sync with heart rate for participants who received physiology feedback. Interactions between two personality factors (neuroticism and anxiety sensitivity) and feedback on the level of self-reported stress were found, indicating that while physiology feedback may be beneficial for individuals high in neuroticism, it may be detrimental for those high in anxiety sensitivity. Additional work is needed to establish how the results of this study may extend beyond immediate effects in a controlled lab setting, but our results do provide a first indication of how self-tracking of physiology may lead to better body awareness and how personality characteristics can help us predict which individuals are most likely to benefit from self-tracking of physiology.

Abstract:

“In the mirror of the Wonder of Luca Giordano” was a multi-sensorial experience created in the gallery frescoed by Luca Giordano in Palazzo Medici Riccardi, in Florence; the project involved different disciplines and researchers. The entire experience was subjected to an impact analysis, combining principally psycho-physiological, qualitative psychological and neuro-physiological aspects. In most of the visitors who participated in the study the experience evoked a sense of pleasure, enjoyment, relaxation, lightness, space-time suspension, involvement and immersiveness. In many of the visitors, the devices detected changes in heartbeat with a stastically significant decrease in blood pressure and heart rate, demontrating that the impact of artwork in a multi-sensorial experience and in an augmented perception environment is a psycho-somatic impact. Our experience suggests that projects such as "In the mirror of the Wonder of Luca Giordano" could be a very useful tool for cultivating emotional intelligence and could be developed in museums alongside the more classical paths of fruition.

Abstract:

AbstractBlood flow restriction (BFR) combined with resistance training (RT-BFR) shows significant benefits in terms of muscle strength and hypertrophy. Such effects have been observed in clinical populations, in groups of physically active people, and among competitive athletes. These effects are comparable or, in some cases, even more efficient compared to conventional resistance training (CRT). RT-BFR stimulates muscle hypertrophy and improves muscle strength even at low external loads. Since no extensive scientific research has been done in relation to groups of athletes, the aim of the present study was to identify technical, physiological and methodological aspects related to the use of RT-BFR in competitive athletes from various sport disciplines. RT-BFR in groups of athletes has an effect not only on the improvement of muscle strength or muscle hypertrophy, but also on specific motor abilities related to a particular sport discipline. The literature review reveals that most experts do not recommend the use RT-BFR as the only training method, but rather as a complementary method to CRT. It is likely that optimal muscle adaptive changes can be induced by a combination of CRT and RT-BFR. Some research has confirmed benefits of using CRT followed by RT-BFR during a training session. The use of BFR in training also requires adequate progression or modifications in the duration of occlusion in a training session, the ratio of exercises performed with BFR to conventional exercises, the value of pressure or the cuff width.